Epithelial injury markers

Summary

The abstract of the review by Burman and colleagues names this candidate biomarker (markers of injury to the airway lining). The abstract states that the biomarkers named may aid risk stratification, patient enrichment and endotype-guided trials. No performance data are stated, and this record is a stub that is unverified beyond the abstract. Only the abstract of the source review was read; the full text was not read.

Sources and links

• Burman et al. 2026, J Heart Lung Transplant (DOI; abstract only was read) (primary)
• PubMed record (PMID 42854767)

Related

Links from this record

• named in (abstract only): CLAD: translating basic science to clinical practice
• candidate for endotype-guided use: Molecular endotypes of CLAD (proposed framework)

Linked from (derived)

• related to: Bronchoalveolar lavage: cell counts, microbiology and protein markers
• reports: Epithelial cell death markers in bronchoalveolar lavage correlate with chronic lung allograft dysfunction subtypes and survival in lung transplant recipients-a single-center retrospective cohort study
• evidence for: Pulmonary epithelial markers in phenotypes of chronic lung allograft dysfunction
• supports: Reduced lung fluid club cell secretory protein informs chronic lung allograft dysfunction risk
• supports: Early posttransplant reductions in club cell secretory protein associate with future risk for chronic allograft dysfunction in lung recipients: results from a multicenter study
• affects: Biomarker findings are hard to validate and generalise across centres
• affects: CLAD is recognised late and no biomarker is validated for early warning

Known gaps in this record

• full text of the source review not read, so the evidence, citations and level of agreement for this item are missing
• funding and conflicts of interest of the source review not read
• assay, performance and validation status not recorded