Early posttransplant reductions in club cell secretory protein associate with future risk for chronic allograft dysfunction in lung recipients: results from a multicenter study
Evidence level: multicentre cohort study; abstract-only
In 392 lung recipients at five centres, lower club cell secretory protein in lavage fluid during the first year after transplant was associated with a higher later risk of probable CLAD.
As of . Primary source: Publisher record via DOI.
Summary
Club cell secretory protein (CCSP) is made by airway club cells. The study measured CCSP and total protein in 1,606 lavage fluid samples collected over the first post-transplant year from 392 adult lung recipients at five centres. According to the abstract, normalised CCSP concentrations were 19 to 48 percent lower in samples with histological allograft injury than in healthy samples. Recipients who had any normalised CCSP level below the median in the first year had a higher risk of probable CLAD, independent of other factors (adjusted hazard ratio 1.95, p = 0.035). The authors state that this supports the use of lavage CCSP for early risk stratification and points to a role for club cell injury in CLAD. The study is observational.
Details
- doi
- 10.1016/j.healun.2023.02.1495
- pmid
- 36941179
- authors
- Todd JL, Weber JM, Kelly FL, Neely ML, Nagler A, Carmack D, Frankel CW, Brass DM, Belperio JA, Budev MM, Hartwig MG, Martinu T, Reynolds JM, Shah PD, Singer LG, Snyder LD, Weigt SS, Palmer SM
- journal
- The Journal of Heart and Lung Transplantation
- year
- 2023
- volume
- 42
- issue
- 6
- pages
- 741-749
Sources and links
- Publisher record via DOI (primary)
- PubMed 36941179
Related
Links from this record
- supports: Epithelial injury markers
- supports: Airway epithelial dysfunction
- coauthor: Tereza Martinu
Linked from (derived)
- author affiliation matches this institution (PubMed): Cleveland Clinic Lung Transplant Program
- author affiliation matches this institution (PubMed): Duke Lung Transplant Program
- author affiliation matches this institution (PubMed): Johns Hopkins Lung Transplant Program
- author affiliation matches this institution (PubMed): UCLA Lung Transplant Program
Known gaps in this record
- full text not read (abstract only)
- funding statement and grant numbers
- author affiliations
- centre or centres not stated in the abstract
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.