Gastro-oesophageal reflux, oesophageal dysmotility and aspiration
Evidence level: abstract-only observational studies; association, not causation
Oesophageal outflow obstruction and major peristalsis disorders are reported to be associated with CLAD in one large Toronto cohort; lavage studies of reflux give mixed findings.
As of . Primary source: Ramendra et al. 2023 (DOI).
Summary
According to the abstract of a Toronto cohort of 487 recipients, oesophagogastric junction outflow obstruction (hazard ratio 1.71) and major disorders of peristalsis (hazard ratio 1.55) were associated with an increased risk of CLAD, while minor disorders were not. The abstract of a lavage study (centre not named) reports that patients with BOS did not have more reflux or pepsin than stable patients, but that bile acids were found in lavage of 70 percent of patients with BOS compared with 31 percent of stable patients, and that proton pump inhibitor treatment did not reduce non-acid reflux or the pepsin and bile levels. The findings are observational and partly inconsistent; this record gives no advice.
Sources and links
Related
Links from this record
- supports: Oesophageal stasis is a risk factor for chronic lung allograft dysfunction and allograft failure in lung transplant recipients.
- supports and qualifies: Gastro-oesophageal reflux and gastric aspiration in lung transplant patients with or without chronic rejection
- related to: Aspiration
- reported association: Bronchiolitis obliterans syndrome (BOS)
Linked from (derived)
Known gaps in this record
- the Blondeau abstract does not name the centre; its link to Leuven is not made
- full text of all sources
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.