Gastro-oesophageal reflux and gastric aspiration in lung transplant patients with or without chronic rejection

Summary

The study characterised gastro-oesophageal reflux with impedance-pH recordings and measured pepsin and bile acids in lavage fluid of lung transplant recipients with and without BOS. According to the abstract, 48 percent of patients had increased reflux, of which 27 percent had exclusively non-acid reflux. Pepsin was found in the lavage fluid of all patients and bile acids in 50 percent. Patients with BOS had neither more reflux nor more pepsin, but 70 percent of patients with BOS had bile in lavage fluid compared with 31 percent of stable patients. Proton pump inhibitor treatment reduced acid reflux but did not reduce non-acid reflux or the pepsin and bile levels. The authors suggest bile acids may be a more specific marker that might be associated with BOS. The number of patients is not stated in the abstract.

Details

doi

10.1183/09031936.00064807

pmid

18057058

authors

Blondeau K, Mertens V, Vanaudenaerde BA, Verleden GM, Van Raemdonck DE, Sifrim D, Dupont LJ

journal

European Respiratory Journal

year

2008

volume

31

issue

4

pages

707-713

publishedOnline

2007-12-05

Sources and links

• Publisher record via DOI (primary)
• PubMed 18057058

Related

Links from this record

• supports: Aspiration
• discusses: Bronchiolitis obliterans syndrome (BOS)

Linked from (derived)

• pepsin and bile acids: Bronchoalveolar lavage: cell counts, microbiology and protein markers
• supports and qualifies: Gastro-oesophageal reflux, oesophageal dysmotility and aspiration

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• author affiliations
• centre or centres not stated in the abstract