Airway colonisation: Pseudomonas and fungal infection
Evidence level: abstract-only observational studies; association, not causation
Pseudomonas airway colonisation and invasive fungal disease are reported to be associated with BOS or RAS in cohort abstracts.
As of . Primary source: Vos et al. 2008 (DOI).
Summary
According to the abstracts read, a Leuven retrospective study of 92 double lung recipients described post-operative pseudomonal colonisation as an independent risk factor for BOS stage 1 or higher, although its multivariate analysis showed only a trend, and reported worse BOS-free survival in univariate analysis; a cohort abstract (Verleden 2013) lists pseudomonal colonisation among factors more frequent before BOS or RAS; and a KU Leuven case-control study reports more Pseudomonas species infection and invasive fungal disease, mainly Aspergillus, in patients with RAS. A lavage microbiota study linked bacterial dysbiosis to inflammatory and remodelling macrophage profiles but reported no CLAD outcome. The studies are observational; this record gives no advice.
Sources and links
Related
Links from this record
- supports: Pseudomonal airway colonisation: risk factor for bronchiolitis obliterans syndrome after lung transplantation?
- supports: Bronchiolitis obliterans syndrome and restrictive allograft syndrome: do risk factors differ?
- supports: Clinical predictors for restrictive allograft syndrome: A nested case-control study.
- related: Airway Microbiota Determines Innate Cell Inflammatory or Tissue Remodeling Profiles in Lung Transplantation
- related to: Microbial dysbiosis
- reported association: Bronchiolitis obliterans syndrome (BOS)
- reported association: Restrictive allograft syndrome (RAS)
Known gaps in this record
- Aspergillus-specific antibody paper (Beeckmans 2023) found but not read
- full text of all sources
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.