Airway Microbiota Determines Innate Cell Inflammatory or Tissue Remodeling Profiles in Lung Transplantation

Summary

The study isolated microbiota DNA and host RNA from 203 bronchoalveolar lavage samples from 112 patients after lung transplantation, determined the bacterial composition by 16S ribosomal RNA analysis, and measured macrophage-related gene expression. According to the abstract, a balanced community of pro-inflammatory (for example Staphylococcus and Pseudomonas) and low-stimulatory bacteria (for example Prevotella and Streptococcus) was linked to non-polarised activation, whereas inflammatory and remodelling profiles were linked to bacterial dysbiosis. Laboratory assays provided direct evidence that dysbiosis could lead to inflammatory or remodelling profiles in macrophages. The authors suggest that crosstalk between bacteria and innate immune cells may determine graft function. CLAD is named as the long-term outcome of concern, but the abstract does not report CLAD outcomes.

Details

doi

10.1164/rccm.201512-2424oc

pmid

27248293

authors

Bernasconi E, Pattaroni C, Koutsokera A, Pison C, Kessler R, Benden C, Soccal PM, Magnan A, Aubert JD, Marsland BJ, Nicod LP

journal

American Journal of Respiratory and Critical Care Medicine

year

2016

volume

194

issue

10

pages

1252-1263

Sources and links

• Publisher record via DOI (primary)
• PubMed 27248293

Related

Links from this record

• supports: Microbial dysbiosis
• related to: Microbiome-derived signals
• supports: Innate immune activation

Linked from (derived)

• microbiota: Bronchoalveolar lavage: cell counts, microbiology and protein markers
• related: Airway colonisation: Pseudomonas and fungal infection
• author affiliation matches this institution (PubMed): Lung transplantation, University Hospital Zurich (USZ)

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• author affiliations
• centre or centres not stated in the abstract