Chronic lung allograft dysfunction: Definition, diagnostic criteria, and approaches to treatment: A consensus report from the Pulmonary Council of the ISHLT

Summary

Consensus report published in the Journal of Heart and Lung Transplantation in May 2019. Its definition of CLAD, as restated in an open-access 2026 validation study, is a sustained loss of at least 20 percent in forced expiratory volume in one second (FEV1) from the post-transplant baseline after other identifiable causes have been excluded and treated. The 2019 report also introduced phenotypes and staging that this site records on separate pages. The full text of this report was not opened for this record; the description above relies on the title, the Crossref metadata and the cited open-access secondary source.

Details

doi

10.1016/j.healun.2019.03.009

pmid

30962148

authors

Verleden GM, Glanville AR, Lease ED, Fisher AJ, Calabrese F, Corris PA, Ensor CR, Gottlieb J, Hachem RR, Lama V, Martinu T, Neil DAH, Singer LG, Snell G, Vos R

journal

The Journal of Heart and Lung Transplantation

year

2019

volume

38

issue

5

pages

493-503

Sources and links

• Publisher record via DOI (primary)
• PubMed 30962148
• Definition restated in Gerckens et al. 2026 (open access)

Related

Links from this record

• defines: Bronchiolitis obliterans syndrome (BOS)
• defines: Restrictive allograft syndrome (RAS)
• defines: Mixed phenotype
• defines: Undefined phenotype
• defines: ISHLT 2019 CLAD states: Potential, Possible, Probable and Definite
• defines: CLAD stages 0 to 4 by FEV1 relative to baseline
• coauthor: Tereza Martinu

Linked from (derived)

• defined in: Bronchiolitis obliterans syndrome (BOS)
• defined in: Mixed phenotype
• defined in: Restrictive allograft syndrome (RAS)
• defined in: Undefined phenotype
• introduced in: CLAD stages 0 to 4 by FEV1 relative to baseline
• introduced in: ISHLT 2019 CLAD states: Potential, Possible, Probable and Definite
• definition source (not opened): Spirometry: FEV1 decline from baseline in the ISHLT 2019 CLAD definition
• uses criteria of: Belumosudil to Block Chronic Lung Allograft Dysfunction (CLAD) in High Risk Lung Transplant Recipients
• author affiliation matches this institution (PubMed): Lung Transplant Service, Alfred Health (The Alfred)
• author affiliation matches this institution (PubMed): Lung transplantation, Hannover Medical School (MHH)
• author affiliation matches this institution (PubMed): Lung Transplant Program, Washington University in St. Louis and Barnes-Jewish Hospital
• coauthor: Tereza Martinu

Known gaps in this record

• abstract (none indexed in PubMed or Europe PMC)
• full text not opened (publisher site blocks automated access)
• funding statement