Kind
Trials
Registered clinical studies related to CLAD.
Trial
Azithromycin in Bronchiolitis Obliterans Syndrome
Evidence: registry entry, results posted by sponsor (quoted as posted)
A completed registered phase 4 randomised placebo-controlled trial of azithromycin in lung transplant recipients, sponsored by KU Leuven, with results posted by the sponsor.
Trial
Extracorporeal Photopheresis for Medicare Recipients of Lung Allografts
Evidence: registry entry; no results posted
A registered phase 3 study of extracorporeal photopheresis (ECP) for progressive bronchiolitis obliterans syndrome in Medicare-eligible lung allograft recipients, sponsored by Washington University School of Medicine.
Trial
A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction
Evidence: registry entry; no results posted
ROCKaspire, a registered phase 3 placebo-controlled trial of belumosudil added to azithromycin and standard immunosuppression in adults with chronic lung allograft dysfunction, sponsored by Sanofi.
Trial
Belumosudil to Block Chronic Lung Allograft Dysfunction (CLAD) in High Risk Lung Transplant Recipients
Evidence: registry entry; no results posted
CTOT-47, a registered phase 2 placebo-controlled trial of belumosudil in lung transplant recipients at high risk of CLAD, sponsored by NIAID.
Trial
Syk Inhibition in MItigating Lung Allograft Rejection (SIMILAR): A Trial to Evaluate the Safety and Tolerability of Fostamatinib in Lung Transplant Patients With Donor-Specific Antibodies
Evidence: registry entry; no results posted
A registered phase 1 trial (SIMILAR) of fostamatinib versus placebo in lung transplant recipients with donor-specific antibodies, sponsored by NHLBI.
Trial
BRIDGE - Blocking Receptor of IL-1β for Donor Graft Edema Reduction
Evidence: registry entry; no results posted
BRIDGE, a registered early phase 1 trial of anakinra added to the donor lung preservation solution to study primary graft dysfunction, sponsored by Northwestern University.
Trial
Plasma and Radiologic Biomarkers of Response to ECP in Lung Transplant Recipients With CLAD
Evidence: registry entry; no results posted
A registered observational study of plasma and MRI biomarkers of response to extracorporeal photopheresis (ECP) in lung transplant recipients with CLAD, sponsored by Brian Keller.
Trial
GRAfT 2.0. A Multimodal Prospective Approach to Define the Mechanisms and Clinical Features of Acute and Chronic Rejection in Lung Transplantation
Evidence: registry entry; no results posted
GRAfT 2.0, a registered observational study of the mechanisms and clinical features of acute and chronic rejection in lung transplantation, sponsored by NHLBI.
Trial
Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging
Evidence: registry entry; no results posted
A registered phase 3 imaging study of the tracer 18F-FAPI-74 PET/CT in people with heart or lung disease that may cause fibrosis, including lung allograft recipients, sponsored by NHLBI.
Trial
Technical Development of Xe MRI
Evidence: registry entry; no results posted
A registered phase 1/2 technical-development study of hyperpolarised xenon-129 MRI in children and adults, including lung transplant recipients, sponsored by Cincinnati Children's Hospital Medical Center.