Chronic lung allograft dysfunction is associated with an increased number of non-HLA antibodies
Evidence level: retrospective multicentre cohort; abstract-only
In a five-centre retrospective study of 226 lung transplant recipients, having several non-HLA antibodies was associated with a higher risk of CLAD.
As of . Primary source: Publisher record via DOI.
Summary
The study analysed non-HLA antibodies in serum taken before and after transplant from 226 lung transplant recipients (100 with CLAD and 126 stable) from five centres, and used a separate cohort to confirm the findings. A panel of 18 non-HLA antibodies was selected because they were more often positive in the CLAD group. Having more than three of these antibodies was independently associated with a higher risk of CLAD, and the risk was higher when they were present after transplant. The presence of both non-HLA antibodies and HLA donor-specific antibodies was associated with a further increased risk of CLAD and graft loss. The authors state that humoral immunity to HLA and non-HLA antigens may contribute to CLAD. The exact hazard ratios are not quoted here because the abstract text could not be read cleanly.
Details
- doi
- 10.1016/j.healun.2023.12.007
- pmid
- 38141896
- authors
- Xu Q, Elrefaei M, Taupin JL, Hitchman KM, Hiho S, Gareau AJ, Iasella CJ, Marrari M, Belousova N, Bettinotti M, Narula T, Alvarez F, Sanchez PG, Levvey B, Westall G, Snell G, Levine DJ, Zeevi A, Roux A
- journal
- The Journal of Heart and Lung Transplantation
- year
- 2024
- volume
- 43
- issue
- 4
- pages
- 663-672
Sources and links
- Publisher record via DOI (primary)
- PubMed 38141896
Related
Links from this record
- supports: Humoral (antibody-mediated) alloimmunity
- supports: Autoantibodies
Linked from (derived)
- supports: HLA donor-specific antibody and non-HLA antibody testing
- author affiliation matches this institution (PubMed): Lung Transplant Service, Alfred Health (The Alfred)
- author affiliation matches this institution (PubMed): Lung transplantation, Hôpital Foch
- author affiliation matches this institution (PubMed): Johns Hopkins Lung Transplant Program
- author affiliation matches this institution (PubMed): Mayo Clinic Lung Transplant Program
- author affiliation matches this institution (PubMed): Stanford Lung Transplant Program
- author affiliation matches this institution (PubMed): UPMC Lung Transplant Program
Known gaps in this record
- full text not read (abstract only)
- funding statement and grant numbers
- author affiliations
- centre or centres not stated in the abstract
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.