Humoral immunity to lung antigens early post-transplant confers risk for chronic lung allograft dysfunction.
Evidence level: retrospective single-centre cohort (89 recipients); abstract-only
A single-centre Toronto study of 89 bilateral lung transplant recipients reporting that certain autoantibodies at 6 months after transplant, and de novo donor-specific antibodies, were associated with CLAD.
As of . Primary source: Publisher record via DOI.
Summary
According to the abstract, serum from 89 crossmatch-negative bilateral recipients was screened at the time of transplant and 6 months later with a custom antigen microarray, before any CLAD diagnosis, and related to de novo donor-specific antibody (dnDSA) exposure and CLAD-free survival. Patients who developed CLAD by 5 years showed a decrease in average IgG reactivity at 6 months. IgG antibodies against tropoelastin, surfactant protein D and thyroglobulin were significantly higher at 6 months in patients who developed CLAD by 5 years, whereas IgG anti-CENP-B (at both time points) and PM/SCL100 (at 6 months) were higher in patients who remained CLAD-free. The abstract states that exposure to autoantibodies against lung-enriched targets and dnDSA conferred increased CLAD risk. The study is observational. Authors include Tereza Martinu and Stephen Juvet.
Details
- doi
- 10.1016/j.healun.2025.02.1577
- pmid
- 39971216
- authors
- Vosoughi D, Ulahannan A, Li Q, Huszti E, Chruscinski A, Birriel D, Madu G, Teskey G, Aversa M, Martinu T, Juvet S
- journal
- The Journal of Heart and Lung Transplantation
- year
- 2025
- volume
- 44
- issue
- 7
- pages
- 1109-1119
Sources and links
- Publisher record via DOI (primary)
- PubMed 39971216
Related
Links from this record
- supports: Humoral (antibody-mediated) alloimmunity
- related to: Autoantibodies
- coauthor: Tereza Martinu
- coauthor: Stephen Juvet
- affiliation named in PubMed record (Toronto Lung Transplant Program): Toronto Lung Transplant Program (University Health Network)
Linked from (derived)
Known gaps in this record
- full text not read (abstract only)
- funding statement and grant numbers
- full author affiliations (only the PubMed affiliation text was checked for named centres)
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.