The ABC of transplant: ALAD, BLAD, and CLAD: definition and significance
Evidence level: expert review; abstract-only
A review by two authors outlines current definitions of ALAD and BLAD alongside CLAD, and states that their definitions and real significance are not yet fully established.
As of . Primary source: Publisher record via DOI.
Summary
Based on the literature and discussions in two ISHLT expert groups, this review describes the definitions, prevalence and outcome of acute lung allograft dysfunction (ALAD) and baseline lung allograft dysfunction (BLAD), and discusses pitfalls in CLAD phenotyping. It states that CLAD has a clear definition although pitfalls in phenotyping persist, and that the definitions and real significance of ALAD and BLAD are not yet fully established and many uncertainties remain.
Details
- doi
- 10.1097/MCP.0000000000001170
- pmid
- 40165763
- authors
- Verleden GM, Bos S
- journal
- Current Opinion in Pulmonary Medicine
- year
- 2025
- volume
- 31
- issue
- 4
- pages
- 397-403
Sources and links
- Publisher record via DOI (primary)
- PubMed 40165763
Related
Links from this record
- defines: Acute lung allograft dysfunction (ALAD)
- discusses: ISHLT 2019 CLAD states: Potential, Possible, Probable and Definite
- authors affiliated with: KU Leuven BREATHE (Laboratory of Respiratory Diseases and Thoracic Surgery)
Linked from (derived)
- author: Geert Verleden
- evidence: Definitions and prognosis of ALAD and BLAD are not settled
Known gaps in this record
- full text not read (abstract only)
- funding statement and grant numbers
- full text and the numerical definitions given (not read)
- funding and conflicts of interest
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.