Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome
Evidence level: small uncontrolled human study; abstract-only
A small 2006 study of 14 patients with BOS that measured airway neutrophils and interleukin-8 before and after azithromycin.
As of . Primary source: Publisher record via DOI.
Summary
Fourteen lung transplant patients with BOS (between stages BOS 0-p and BOS 3) were given azithromycin in addition to their existing immunosuppression, and bronchoalveolar lavage was performed before and three months after the start. According to the abstract, FEV1 rose from a mean of 2.36 litres to 2.67 litres and the percentage of lavage neutrophils fell from 35.1 to 5.7 percent. Six patients were responders (FEV1 increase above 10 percent) and eight were not. Responders had higher initial lavage neutrophils and interleukin-8 and had started treatment earlier after transplantation. The authors conclude that azithromycin reduces airway neutrophilia and interleukin-8 messenger RNA in BOS, and that lavage neutrophilia may predict the FEV1 response. The study is small and uncontrolled. This summary describes the literature and is not medical advice.
Details
- doi
- 10.1164/rccm.200601-071oc
- pmid
- 16741151
- authors
- Verleden GM, Vanaudenaerde BM, Dupont LJ, Van Raemdonck DE
- journal
- American Journal of Respiratory and Critical Care Medicine
- year
- 2006
- volume
- 174
- issue
- 5
- pages
- 566-570
Sources and links
- Publisher record via DOI (primary)
- PubMed 16741151
Related
Links from this record
- studies treatment of: Bronchiolitis obliterans syndrome (BOS)
Linked from (derived)
- described in: Azithromycin
Known gaps in this record
- full text not read (abstract only)
- funding statement and grant numbers
- author affiliations
- centre or centres not stated in the abstract
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.