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Paper

Hyaluronan Contributes to Bronchiolitis Obliterans Syndrome and Stimulates Lung Allograft Rejection through Activation of Innate Immunity

Evidence level: clinical sample analysis with mouse lung transplant experiments; abstract-only

Hyaluronan was raised in recipients with BOS, and in mice it stimulated lung allograft rejection through innate immune signalling.

As of . Primary source: Publisher record via DOI.

Summary

The study measured hyaluronan (HA), a component of the tissue matrix, in lavage and plasma samples from lung recipients with or without established BOS. According to the abstract, HA was found within areas of small-airway fibrosis in BOS lung tissue, transcripts for HA-making enzymes were higher in BOS tissue, and lavage and plasma HA concentrations were higher in recipients with BOS. In mouse lung transplant recipients with established tolerance, low-molecular-weight HA broke tolerance through TLR2/4 and MyD88 signalling and expanded alloantigen-specific T cells, and neutrophil recruitment promoted rejection, while high-molecular-weight HA reduced baseline inflammation. The authors suggest HA accumulation could contribute to BOS by activating innate immune pathways. The numbers of patients are not stated in the abstract.

Details

doi
10.1164/rccm.201308-1481oc
pmid
24471427
authors
Todd JL, Wang X, Sugimoto S, Kennedy VE, Zhang HL, Pavlisko EN, Kelly FL, Huang H, Kreisel D, Palmer SM, Gelman AE
journal
American Journal of Respiratory and Critical Care Medicine
year
2014
volume
189
issue
5
pages
556-566

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Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.