Donor and recipient human leukocyte antigen-G polymorphisms modulate the risk of adverse immunologic events following lung transplantation

Summary

This retrospective cohort of 289 bilateral lung transplants analysed recipient and donor HLA-G genotypes against de novo donor-specific antibodies, acute rejection, CLAD and allograft survival. According to the abstract, donor HLA-G single nucleotide polymorphisms were associated with allograft injury, CLAD onset following injury and allograft survival; recipient polymorphisms were associated with injury, cellular rejection and antibody formation; and low-expression donor haplotypes and donor-recipient pairs were associated with impaired allograft survival. The authors conclude that both genotypes influence immunologic risk. It is a genetic association study and has not been shown to be causal.

Details

doi

10.1016/j.ajt.2022.12.008

pmid

36695689

authors

Riddell P, Ma J, Lazarte J, Birriel D, Ulahannan A, Ghany R, Delgado D, Rao V, Keshavjee S, Martinu T, Tikkanen J, Juvet SC

journal

American Journal of Transplantation

year

2023

volume

23

issue

3

pages

393-400

Sources and links

• Publisher record via DOI (primary)
• PubMed 36695689

Related

Links from this record

• relates to: Antibody-mediated rejection and donor-specific antibodies
• relates to: Acute cellular rejection
• authors affiliated with: Toronto Lung Transplant Program (University Health Network)
• coauthor: Shaf Keshavjee
• coauthor: Tereza Martinu
• coauthor: Stephen Juvet

Linked from (derived)

• author: Shaf Keshavjee
• author: Stephen Juvet
• author: Tereza Martinu

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• external replication