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Restrictive allograft syndrome post lung transplantation is characterized by pleuroparenchymal fibroelastosis

Evidence level: retrospective human tissue study; abstract-only

A histopathology study reporting pleuroparenchymal fibroelastosis as a major tissue correlate of restrictive allograft syndrome.

As of . Primary source: Publisher record via DOI.

Summary

This retrospective study reviewed 493 patients who underwent lung transplantation between 1996 and mid-2009. Of 47 patients with clinical features of restrictive allograft syndrome (RAS), 16 had lung tissue available from wedge biopsy, retransplant explant or autopsy. According to the abstract, all 16 showed pleural fibrosis and 15 showed parenchymal fibroelastosis, mostly beneath the pleura. Features of obliterative bronchiolitis were present in 14 cases, and diffuse alveolar damage in 13 cases, usually in specimens taken less than one year after clinical onset. The authors conclude that pleuroparenchymal fibroelastosis is a major histopathologic correlate of RAS and that the findings support diffuse alveolar damage followed by pleuroparenchymal fibroelastosis in the evolution of RAS. The study design is retrospective and the numbers are small.

Details

doi
10.1038/modpathol.2012.171
pmid
23018877
authors
Ofek E, Sato M, Saito T, Wagnetz U, Roberts HC, Chaparro C, Waddell TK, Singer LG, Hutcheon MA, Keshavjee S, Hwang DM
journal
Modern Pathology
year
2013
volume
26
issue
3
pages
350-356

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