Emergence of a senescent and inflammatory pulmonary CD4+ T cell population prior to lung allograft failure

Summary

The authors used time-of-flight mass cytometry on bronchoalveolar lavage to find cells enriched in patients who later developed acute lung allograft dysfunction (ALAD), a risk factor for CLAD. According to the abstract, CD4+CD57+PD1+ T cells emerge in clinically stable patients and confer risk for ALAD, CLAD and death. The cells are senescent, secrete inflammatory cytokines and fall into two oligoclonal subsets with putative cytotoxic and follicular helper functions. They were associated with fibrosis in mouse and human lung allografts, where they localise near airway epithelium and B cells. The authors suggest this population may be a rational therapeutic target. Cohort sizes are not stated in the abstract.

Details

doi

10.1126/sciadv.adp9052

pmid

40117366

authors

Moshkelgosha S, Levy L, Safavi S, Karunagaran S, Wilson G, Renaud-Picard B, Madu G, Ramchandani R, Oliver J, Watanabe T, Bei KF, Joe B, Li Q, Huszti E, Cheung M, Hedley D, Yeung J, Keshavjee S, Martinu T, Juvet S

journal

Science Advances

year

2025

volume

11

issue

12

Sources and links

• Publisher record via DOI (primary)
• PubMed 40117366

Related

Links from this record

• describes: Cytotoxic and senescent T cells
• describes risk for: Acute lung allograft dysfunction (ALAD)
• uses: Bronchoalveolar lavage: cell counts, microbiology and protein markers
• authors affiliated with: Toronto Lung Transplant Program (University Health Network)
• coauthor: Shaf Keshavjee
• coauthor: Tereza Martinu
• coauthor: Stephen Juvet

Linked from (derived)

• author: Shaf Keshavjee
• author: Stephen Juvet
• author: Tereza Martinu
• evidence: Definitions and prognosis of ALAD and BLAD are not settled

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• cohort sizes and number of patients