Shared roles of immune and stromal cells in the pathogenesis of human bronchiolitis obliterans syndrome

Summary

The study performed single-cell RNA sequencing on explanted human lungs from 4 patients with CLAD-BOS, 3 patients with BOS caused by chronic graft-versus-host disease after stem cell transplant, and 3 deceased controls. In both forms of BOS the authors found an expanded population of CD8 tissue-resident memory T cells that was distinct from other chronic lung diseases. BOS samples also expressed genes linked to macrophage chemotaxis and proliferation, including in non-immune cells, and showed dysfunctional stromal cells with both pro- and anti-fibrotic gene programs. The authors suggest substantial overlap between the two forms of BOS and common pathways for possible treatment. The sample is very small.

Details

doi

10.1172/jci.insight.176596

pmid

40232854

authors

Mellors PW, Lange AN, Casino Remondo B, Shestov M, Planer JD, Peterson AR, Ying Y, Zhou S, Christie JD, Diamond JM, Cantu E, Basil MC, Gill S

journal

JCI Insight

year

2025

volume

10

issue

10

articleNumber

e176596

Sources and links

• Publisher record via DOI (primary)
• PubMed 40232854

Related

Links from this record

• supports: Cytotoxic and senescent T cells
• related to: Innate immune activation
• discusses: Bronchiolitis obliterans syndrome (BOS)

Linked from (derived)

• author affiliation matches this institution (PubMed): Penn Medicine Lung Transplant Program (Penn Transplant Institute)

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
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• centre or centres not stated in the abstract