An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants

Summary

In mouse orthotopic lung transplants with conditional depletion of club cells, the abstract reports that syngeneic grafts repaired the airway lining quickly, whereas allogeneic grafts developed severe obliterative bronchiolitis lesions and regenerated club cells poorly despite immunosuppression. Club cell loss in allografts also triggered recognition of alloantigens and of lung self-antigens reported to be associated with BOS. Depleting CD8 T cells restored club cell repair and prevented the lesions, and laboratory tests pointed to a specific role for alloantigen-primed effector CD8 T cells in preventing club cell proliferation. The authors propose a new model for studying obliterative bronchiolitis. The findings come from mice.

Details

doi

10.1172/jci.insight.124732

pmid

30990794

authors

Liu Z, Liao F, Scozzi D, Furuya Y, Pugh KN, Hachem R, Chen DL, Cano M, Green JM, Krupnick AS, Kreisel D, Perl AKT, Huang HJ, Brody SL, Gelman AE

journal

JCI Insight

year

2019

volume

4

issue

9

articleNumber

e124732

Sources and links

• Publisher record via DOI (primary)
• PubMed 30990794

Related

Links from this record

• supports: Airway epithelial dysfunction
• supports: Cytotoxic and senescent T cells
• discusses: Bronchiolitis obliterans syndrome (BOS)

Linked from (derived)

• author affiliation matches this institution (PubMed): Lung Transplant Program, Washington University in St. Louis and Barnes-Jewish Hospital

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• author affiliations
• centre or centres not stated in the abstract