Distinct fibrotic, epithelial and immune transcriptomic programs in phenotypes of chronic lung allograft dysfunction

Summary

Preprint, not peer reviewed. The study used bulk RNA sequencing of explanted lung tissue from 45 recipients with end-stage CLAD, of whom 20 had a restrictive-pattern chest imaging finding (RLO) and 25 did not. These were compared with 27 control donor and lobectomy lungs and 16 lungs with idiopathic pulmonary fibrosis (IPF). Findings have not been peer reviewed and should be read as preliminary. The details of the findings were not recorded here beyond the study design.

Details

doi

10.64898/2026.05.24.727536

journal

bioRxiv (preprint)

year

2026

posted

2026-05-28

version

v1

authors

Ishiwata T, Berra G, Allen J, Burman A, Wilson G, Carter Z, Watanabe T, Solomon M, Keshavjee S, Yeung J, Juvet S, Martinu T

Sources and links

• bioRxiv record via DOI (primary)

Related

Links from this record

• author: Stephen Juvet
• author (last author): Tereza Martinu
• affiliation (most authors): Toronto Lung Transplant Program (University Health Network)
• discusses: Bronchiolitis obliterans syndrome (BOS)
• discusses: Restrictive allograft syndrome (RAS)

Linked from (derived)

• possibly related (relationship unconfirmed): Molecular endotypes of CLAD (proposed framework)
• describes RLO group: Chest CT: parenchymal patterns and density in CLAD
• cited in reference list (per Crossref); relationship unconfirmed: Toward molecular endotypes of CLAD: dancing around the truth hidden in the tissue
• author: Shaf Keshavjee

Known gaps in this record

• funding statement
• peer-reviewed publication (none found as of asOf)
• findings not summarised in this record
• affiliations of individual authors not all recorded