Quantitative chest CT for subtyping chronic lung allograft dysfunction and its association with survival.
Evidence level: retrospective single-centre imaging study (74 patients); abstract-only
A Toronto retrospective study of quantitative chest CT density in 74 patients at CLAD onset, reporting that higher density values were associated with shorter survival.
As of . Primary source: Publisher record via DOI.
Summary
According to the abstract, restrictive allograft syndrome (RAS) shows increased overall CT lung density, in contrast to bronchiolitis obliterans syndrome (BOS), which shows reduced density. The study calculated two reader-independent density metrics (QDM1 and QDM2) from CT lung density histograms, using CT scans corresponding to CLAD onset in 74 patients (23 RAS, 51 BOS). Higher metric values were significantly associated with decreased survival; the hazard ratio for death was 3.2 times higher at the 75th percentile than at the 25th percentile using QDM1 in a univariate model. The authors state that the metric may associate with CLAD prognosis. The study is retrospective and single-programme. The authors include Tereza Martinu and Shaf Keshavjee.
Details
- doi
- 10.1111/ctr.13233
- pmid
- 29637624
- authors
- Horie M, Salazar P, Saito T, Binnie M, Brock K, Yasufuku K, Azad S, Keshavjee S, Martinu T, Paul N
- journal
- Clinical Transplantation
- year
- 2018
- volume
- 32
- issue
- 5
- articleNumber
- e13233
- publishedOnline
- 2018-04-10
Sources and links
- Publisher record via DOI (primary)
- PubMed 29637624
Related
Links from this record
- discusses: Bronchiolitis obliterans syndrome (BOS)
- discusses: Restrictive allograft syndrome (RAS)
- coauthor: Tereza Martinu
- affiliation named in PubMed record (Toronto Lung Transplant Program): Toronto Lung Transplant Program (University Health Network)
Linked from (derived)
- supports: Chest CT: parenchymal patterns and density in CLAD
- author: Shaf Keshavjee
Known gaps in this record
- full text not read (abstract only)
- funding statement and grant numbers
- full author affiliations (only the PubMed affiliation text was checked for named centres)
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.