Long-term Outcomes of Lung Transplant With Ex Vivo Lung Perfusion
Evidence level: retrospective single-centre cohort; abstract-only
A Toronto cohort study comparing long-term CLAD incidence and allograft survival after transplant with and without ex vivo lung perfusion (EVLP).
As of . Primary source: Publisher record via DOI.
Summary
This retrospective single-centre cohort study at the Toronto Lung Transplant Program covered transplants from August 2008 to February 2017, with 706 recipients of lungs not treated with EVLP and 230 recipients of lungs treated with EVLP. The primary outcomes were the incidence of CLAD and allograft survival. According to the abstract, there was no significant difference between the groups in time to CLAD or in allograft survival, and secondary outcomes were similar. The authors conclude that use of EVLP-treated lungs increased the number of patients undergoing transplantation, with comparable long-term outcomes. This is an observational comparison and does not show cause and effect.
Details
- doi
- 10.1001/jamasurg.2019.4079
- pmid
- 31596484
- authors
- Divithotawela C, Cypel M, Martinu T, Singer LG, Binnie M, Chow CW, Chaparro C, Waddell TK, de Perrot M, Pierre A, Yasufuku K, Yeung JC, Donahoe L, Keshavjee S, Tikkanen JM
- journal
- JAMA Surgery
- year
- 2019
- volume
- 154
- issue
- 12
- pages
- 1143
Sources and links
- Publisher record via DOI (primary)
- PubMed 31596484
Related
Links from this record
- describes outcomes at: Toronto Lung Transplant Program (University Health Network)
- coauthor: Tereza Martinu
Linked from (derived)
- author: Lianne Singer
- author: Marcelo Cypel
- author: Shaf Keshavjee
Known gaps in this record
- full text not read (abstract only)
- funding statement and grant numbers
- author affiliations
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.