Impact of Immediate Primary Lung Allograft Dysfunction on Bronchiolitis Obliterans Syndrome.
Evidence level: retrospective single-centre cohort (334 recipients); abstract-only
A single-centre cohort of 334 lung transplant recipients reporting that primary graft dysfunction was associated with a higher risk of BOS, increasing with its grade.
As of . Primary source: Publisher record via DOI.
Summary
According to the abstract, 334 adult recipients were graded for primary graft dysfunction (PGD) by the ISHLT definition (65 grade 0, 130 grade 1, 69 grade 2 and 70 grade 3). In univariable analysis all grades of PGD were associated with an increased risk of BOS stage 1 (relative risk 1.73 for grade 1, 2.13 for grade 2 and 2.53 for grade 3, compared with grade 0). The abstract reports that the association was independent of acute rejection, lymphocytic bronchitis and community-acquired respiratory viral infections in a multivariable model, and that PGD was not associated with acute rejection or lymphocytic bronchitis. The design is a retrospective cohort and shows association.
Details
- doi
- 10.1164/rccm.200608-1079OC
- pmid
- 17158279
- authors
- Daud SA, Yusen RD, Meyers BF, Chakinala MM, Walter MJ, Aloush AA, Patterson GA, Trulock EP, Hachem RR
- journal
- American Journal of Respiratory and Critical Care Medicine
- year
- 2007
- volume
- 175
- issue
- 5
- pages
- 507-513
- publishedOnline
- 2007-03-01
Sources and links
- Publisher record via DOI (primary)
- PubMed 17158279
Related
Links from this record
- discusses: Bronchiolitis obliterans syndrome (BOS)
Linked from (derived)
- supports: Primary graft dysfunction
Known gaps in this record
- full text not read (abstract only)
- funding statement and grant numbers
- full author affiliations (only the PubMed affiliation text was checked for named centres)
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.