International Society for Heart and Lung Transplantation Scientific Statement on pulmonary antibody-mediated rejection and proposed graft, antibody, and pathology (GAP) definition
Evidence level: scientific statement (modified Delphi); abstract-only
An ISHLT scientific statement proposes a multidimensional GAP definition of pulmonary antibody-mediated rejection and notes a 2-year survival of only 20 percent.
As of . Primary source: Publisher record via DOI.
Summary
An ISHLT workgroup of nine subgroups used a modified Delphi method to update the 2016 definition of antibody-mediated rejection (AMR). The resulting Graft, Antibody and Pathology (GAP) definition reports graft dysfunction, antibody presence and characteristics, and pathological findings. The statement says outcomes remain dismal with a 2-year survival of only 20 percent, and identifies better treatments as a critical unmet need, proposing that a more precise definition could provide a platform for testing new therapies.
Details
- doi
- 10.1016/j.healun.2026.04.019
- pmid
- 42274447
- authors
- Calabrese F, Levine DJ, Adam BA, Agbor-Enoh S, Benden C, Budev MM, Cochrane AB, Cozzi E, Darley DR, Fishbein GA, Gelman AE, Glanville AR, Greenland JR, Hickey MJ, Ius F, Jaksch P, Jackson AM, Joerns JO, Lor H, Lowery EM, Mangiola M, Morlacchi LC, Murray MA, Nair A, Ocagli H, Parmar JS, Pavlisko EN, Perch M, Rahaghi FF, Roden AC, Roux A, Snyder L, Sweet S, Verleden SE, Visner GA, Vos R, Wikenheiser-Brokamp KA, Zeevi A, Hachem RR
- journal
- The Journal of Heart and Lung Transplantation
- year
- 2026
- volume
- 45
- issue
- 9
- pages
- 1357-1374
Sources and links
- Publisher record via DOI (primary)
- PubMed 42274447
Related
Links from this record
- defines: Antibody-mediated rejection and donor-specific antibodies
- discusses: HLA donor-specific antibody and non-HLA antibody testing
- authors affiliated with: KU Leuven BREATHE (Laboratory of Respiratory Diseases and Thoracic Surgery)
- coauthor: Robin Vos
Linked from (derived)
- author affiliation matches this institution (OpenAlex): Newcastle Lung Transplant Programme (Freeman Hospital and Newcastle University)
- author affiliation matches this institution (OpenAlex): St Vincent's Hospital Sydney Heart and Lung Transplant Unit
- author affiliation matches this institution (OpenAlex): UCSF Lung Transplant Program
- author: Robin Vos
- evidence: Pulmonary antibody-mediated rejection has dismal outcomes and no established treatment platform
Known gaps in this record
- full text not read (abstract only)
- funding statement and grant numbers
- the GAP criteria and thresholds (full text not read)
- funding and conflicts of interest
Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.