Skip to content
CLADsolve

Paper

Macrophage and CD8 T cell discordance are associated with acute lung allograft dysfunction progression

Evidence level: prospective single-cell RNA sequencing cohort; abstract-only

Lavage cell sequencing in 45 recipients found a macrophage cluster and a CD8 T cell cluster that distinguished ALAD with later decline from ALAD that recovered or stable function.

As of . Primary source: Publisher record via DOI.

Summary

Acute lung allograft dysfunction (ALAD) is an imprecise syndrome that raises concern for the onset of CLAD. The study collected bronchoalveolar lavage prospectively for single-cell RNA sequencing from 17 ALAD cases with subsequent decline, 13 ALAD cases that resolved and 15 recipients with stable lung function. A CD8 T cell cluster resembling tissue-resident memory cells and a macrophage cluster with an anti-inflammatory signature best identified the ALAD cases with decline. The abstract reports that these macrophages signalled to activated CD8 T cells through several pathways. The authors suggest that anti-inflammatory lavage macrophages may protect against CLAD by suppressing CD8 T cells, and state that these populations merit further assessment in additional cohorts. The suggestion is a hypothesis, not a demonstrated mechanism.

Details

doi
10.1016/j.healun.2024.02.007
pmid
38367738
authors
Calabrese DR, Ekstrand CA, Yellamilli S, Singer JP, Hays SR, Leard LE, Shah RJ, Venado A, Kolaitis NA, Perez A, Combes A, Greenland JR
journal
The Journal of Heart and Lung Transplantation
year
2024
volume
43
issue
7
pages
1074-1086

Sources and links

Related

Links from this record

Linked from (derived)

Known gaps in this record

  • full text not read (abstract only)
  • funding statement and grant numbers
  • author affiliations
  • centre or centres not stated in the abstract

Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.