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Paper

IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants

Evidence level: prospective immunological cohort; abstract-only

Immune cell responses to collagen type V, driven by IL-17 and monocytes, were linked to more frequent and more severe BOS in lung transplant recipients.

As of . Primary source: Publisher record via DOI.

Summary

The abstract describes blood cell responses to collagen type V that were monitored prospectively over seven years in lung transplant recipients. These responses were frequently present in transplant recipients but not in healthy controls or in a comparison group of patients with Goodpasture's syndrome who had received a kidney transplant. They depended on CD4 T cells and monocytes and required IL-17, TNF-alpha and IL-1 beta. Strong collagen V responses were associated with a substantially higher incidence and severity of BOS, more strongly than acute rejection, HLA mismatch or HLA antibodies. The authors suggest that alloimmunity starts lung transplant rejection, while autoimmunity to collagen V mediated by Th17 cells and monocyte or macrophage helper cells drives progressive airway obliteration. The number of patients is not stated in the abstract.

Details

doi
10.1172/jci28031
pmid
17965778
authors
Burlingham WJ, Love RB, Jankowska-Gan E, Haynes LD, Xu Q, Bobadilla JL, Meyer KC, Hayney MS, Braun RK, Greenspan DS, Gopalakrishnan B, Cai J, Brand DD, Yoshida S, Cummings OW, Wilkes DS
journal
Journal of Clinical Investigation
year
2007
volume
117
issue
11
pages
3498-3506

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Information resource only. Not medical advice. Not a substitute for the care of the patient's transplant team.