Center variability in the prognostic value of a cumulative acute cellular rejection "A-score" for long-term lung transplant outcomes

Summary

This study asked whether the A-score, the average acute cellular rejection grade across transbronchial biopsies, associates with CLAD or graft failure in two geographically distinct cohorts: a primary cohort of 772 double lung recipients and an independent cohort of 300. In the primary cohort no association was found between A-score and graft outcome. In the comparison cohort, the time-dependent A-score was associated with CLAD (hazard ratio 1.51) and, at 6 months, hazard ratio 1.355. The authors conclude the A-score is useful in some settings but not generalisable across centres.

Details

doi

10.1016/j.ajt.2023.08.014

pmid

37625646

authors

Belousova N, Huszti E, Li Q, Vasileva A, Ghany R, Gabarin R, El Sanharawi M, Picard C, Hwang D, Levy L, Keshavjee S, Chow CW, Roux A, Martinu T

journal

American Journal of Transplantation

year

2024

volume

24

issue

1

pages

89-103

Sources and links

• Publisher record via DOI (primary)
• PubMed 37625646

Related

Links from this record

• studies: Acute cellular rejection
• uses: Transbronchial biopsy: histology and transcript-based classifiers
• authors affiliated with: Toronto Lung Transplant Program (University Health Network)
• coauthor: Shaf Keshavjee
• coauthor: Tereza Martinu

Linked from (derived)

• author: Shaf Keshavjee
• author: Tereza Martinu
• evidence: Biomarker findings are hard to validate and generalise across centres

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• names of the two cohort centres (not stated in abstract)