The CD8+ T cell content of transbronchial biopsies from patients with a first episode of clinically stable grade A1 cellular rejection is associated with future chronic lung allograft dysfunction

Summary

Sixty-two patients with a first episode of clinically stable grade A1 acute cellular rejection were divided into those with CLAD within 2 years (n=13) and those CLAD-free for 5 or more years (n=49). Imaging mass cytometry on a subcohort of 16 revealed 50 immune cell subpopulations. Methylation and immunofluorescence analyses showed no significant difference in regulatory T cells between groups, while immunofluorescence showed greater CD8+ T cell infiltration in patients who developed CLAD within 2 years. The authors conclude greater CD8+ T cell content may indicate a worse long-term outlook. It is a small retrospective comparison.

Details

doi

10.1016/j.healun.2024.06.001

pmid

38852935

authors

Beber SA, Moshkelgosha S, White M, Zehong G, Cheung M, Hedley D, Levy L, Samuels J, Renaud-Picard B, Hwang D, Martinu T, Juvet S

journal

The Journal of Heart and Lung Transplantation

year

2024

volume

43

issue

10

pages

1654-1664

Sources and links

• Publisher record via DOI (primary)
• PubMed 38852935

Related

Links from this record

• studies: Acute cellular rejection
• describes: Cytotoxic and senescent T cells
• uses: Transbronchial biopsy: histology and transcript-based classifiers
• authors affiliated with: Toronto Lung Transplant Program (University Health Network)
• coauthor: Tereza Martinu
• coauthor: Stephen Juvet

Linked from (derived)

• author: Stephen Juvet
• author: Tereza Martinu

Known gaps in this record

• full text not read (abstract only)
• funding statement and grant numbers
• validation in an independent cohort